KSM-66® Ashwagandha scientific studies

Valued in Ayurvedic practices, Ashwagandha supports mental and physical well-being, emotional balance, and relaxation. KSM-66® Ashwagandha, the most scientifically studied full-spectrum root extract, retains natural compounds while delivering the highest concentration of active withanolides. While most studies focus on adults, emerging evidence suggests potential benefits for children's health.

What makes KSM-66® Ashwagandha unique?

• It’s a patented full-spectrum extract, which means it maintains the natural profile of the whole root, providing a delicate balance of the various active compounds found in the original herb, rather than isolating one compound.
• It contains the highest concentration of root-only extract >5% withanolides, which are the active compounds linked to Ashwagandha’s attributes.
• Using a ‘Green Chemistry’ extraction process, made without alcohol or chemical solvents.
• Certified to organic standards and conforms to both EU and US standards.
• KSM-66® Ashwagandha is non-GMO Project verified. This means that genetically modified organisms are fully prohibited throughout all aspects of farming and processing.
• Gluten-free, Kosher, Halal, HACCP, and more.
• Scientifically studied - it has 35 published “gold-standard' scientific trials.
• End-to-end product control – we use the only Ashwagandha manufacturer with its own production facilities, testing laboratories, research centre and distribution.
• Tested by third-party laboratories to ensure the utmost purity.
  

 

Supported by two recent studies in children aged 5 to 12 years (currently under peer review), KSM-66Ⓡ Ashwagandha shows promising outcomes as a safe, effective and trusted botanical for children’s health.

 

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STUDY 1

Effects of KSM-66® Ashwagandha on memory, attention, executive function, and sleep in children: a randomised, double-blind, placebo-controlled study

Under peer review

How was it conducted?

• A randomised, double blind, 2-arm parallel-group, placebo-controlled trial

• The study was conducted over a period of 8 weeks

• 80 healthy participants were recruited, aged 6–12 years old

• Parent-reported concerns in the child’s attention, concentration and memory

• Each child was provided with 300 mg of KSM-66® Ashwagandha root extract, daily, in divided doses.

• The exclusion criteria included children:

  • with any current or 12-month history of medical conditions, such as diabetes, cardiovascular disease

  • affected by ADHD and any other diagnosed learning disorders

  • taking nutraceuticals or medication

  • who are experiencing exceptional social /family stressors

 

What benefits were they seeking?

• To evaluate the impact Ashwagandha KSM-66Ⓡ could have on cognition, behaviour, sleep, and overall function in children aged 6-12 years

 

What did they find?

• Significant improvements in episodic memory, working memory, attention, and processing speed.
• Better executive function, helping with organisation and focus.
• Improved sleep behaviours based on the Sleep Disturbance Scale for Children, indicating better sleep-related behaviour in children.
• Safe and well-tolerated, with only minor adverse effects comparable to the placebo group and no serious adverse events.
  

A daily intake of Ashwagandha KSM-66® has been found to be safe and effective in supporting children’s sleep quality, memory and cognition.

 

 

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STUDY 2

Title: A Prospective, Double Blind, Randomised, Parallel, Single-Centre, Two-Arm, Placebo-Controlled Clinical Study to Assess the Efficacy and Safety of Ashwagandha Root Extract (150mg) for the Management of the Mild Form of Attention Deficit Hyperactivity Disorder (ADHD) in Children and Adolescents

Under peer review

How was it conducted?

• A prospective, double blind, randomised, randomised, double blind, 2-arm parallel-group, placebo-controlled trial

• The study was conducted over a period of 8 weeks

• 58 participants with a mild form of ADHD according to DSM IV criteria, including clinical interview, were recruited

• Children and teenagers were aged between 5 and 12 years old

• Each child was provided with 300 mg of KSM-66® Ashwagandha root extract, daily, in divided doses.

• Exclusion criteria included patients who were:

  • On any stimulant or non-stimulant pharmacotherapy for ADHD before study start/screening

  • Diagnosed with additional mental health disorders such as Obsessive Compulsive Disorder (OCD), major depressive disorders or mood disorders.

  • Hypersensitive to the study product or placebo.

  • Using vitamin or mineral supplements, nutritional supplements and or medical foods within 30 days before the commencement of the study or during the study.

  • Using prescription medications and/or non-prescription medications for acute medical conditions, semi-acute medical conditions, and weight loss.

  • Who had participated in other clinical trials during the previous 3 months.
    

Any other condition that the principal investigator thinks may jeopardise the safety of patients with uncontrolled, unstable comorbidities.

 

What benefits were they seeking?

• Primary objective

  • To evaluate the efficacy of the Ashwagandha formulation in children and adolescents with ADHD with respect to change in the ADHD Rating Scale IV.
    

• Secondary Objectives:
  • To evaluate the safety and tolerability of the Ashwagandha formulation.
  • To evaluate the effect of Ashwagandha formulation with respect to the quality of life of these subjects from baseline to the end of treatment.

 

What did they find?

• Significant reductions in inattention, hyperactivity and impulsivity scores.

• A reduction in sleep disturbances and a feeling of worry

• No significant impact on liver or kidney health markers.

• Safe and well-tolerated, with no serious adverse effects.
  

 

Summary: KSM-66® Ashwagandha may offer gentle, supportive benefits for children’s attention, sleep, and behavioural wellbeing.